摘要 |
<p>1,154,120. 3-Methyl-19-nor-#<SP>3</SP><SP>-5</SP>-androstadienes. E. MERCK A.G. 20 May, 1968 [15 July, 1967], No. 23955/68. Heading C2U. The novel compounds 3-methyl-17α-(al]yl and ethynyl) - 19 - nor - 3,5 - androstadien - 17# - ols are prepared by isomerization of the corresponding 3 - methylene - 4 - androstenes. Isomerization is preferably effected with an acidic agent. 3 - Methylene - 17α - (allyl and ethynyl) -19 - nor - 4 - androsten - 17# - ols are prepared from the corresponding 3-ones and triphenyl phosphine methylene. The 3-methyl steroids of the invention, which are stated to have ovulation-inhibiting, anti-fertility, estrogenic and anti-estrogenic action, may be made up into pharmaceutical compositions with suitable carriers.</p> |