摘要 |
NEW MATERIAL:4-(4-Pyridyl)pimelic acid hydrochloride of formula III. USE:Intermediate for agricultural chemicals and pharmaceuticals or a raw material for polymer containing pyridyl group. PREPARATION:The objective compound of formula III can be produced by (1) reacting pyridylacetonitrile of formula II with an acrylic acid ester of formula IV (R is CH3 or C2H5) in an organic solvent or in the absence of solvent at room temperature - 50 deg.C in the presence of a base such as 1,8- diazabicyclo[5.4.0]-7-undecene, etc., as a catalyst and (2) heating and reacting the resultant 4-cyano-4-(4-pyridyl)pimelic acid ester of formula I in hydrochloric acid, thereby effecting the simultaneous hydrolysis of cyano group, decarbonation of the compound and hydrolysis of the ester group R.
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