| 摘要 |
PURPOSE:To obtain the titled compound in high yield and selectivity, shortening the oxidation reaction time, by using p-cresol as a raw material and oxidizing the alkyl group of p-cresol with molecular O2 in an alcohol solvent in the presence of a specific mixed catalyst and a base. CONSTITUTION:The objective compound is produced by oxidizing p-cresol with molecular O2 in the presence of a mixed catalyst consisting of an iron (III) compound and a nickel (II) compound and a base such as sodium hydroxide in an alcohol solvent (especially preferably methanol, etc.) at 60-80 deg.C under >=1atm pressure for about 1hr. The iron (III) compound is e.g. ferric chloride, ferric sulfate, ferric oxide, etc., and especially preferably ferric chloride. The nickel (II) compound is nickel chloride, nickel bromide, nickel carbonate, etc., and especially preferably nickel chloride. The sum of both catalyst compound is preferably >=0.001mol per 1mol or p-cresol and the molar ratio of Ni/Fe in the catalyst is 0.05-5.
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