Novel intermediates of cephalosporins and process for producing 7-(substituted or unsubstituted amino)-3-substituted methyl- DELTA 3-cephem-4-carboxylic acids

摘要

This invention relates to novel 7-(substituted or unsubstituted amino)-3-substituted methyl- DELTA 3-cephem-4-carboxylic acids in which a substituted or unsubstituted 1,2,4-triazolyl or 2-(1,2,3,4-tetrazolyl) group attaches to the exomethylene group at the 3-position of the cephem ring through a carbon-nitrogen bond. These cephalosporins are useful intermediates for producing various novel cephalosporins. Also, this invention concerns a process for producing a compound represented by the formula: <IMAGE> which comprises reacting a compound represented by the formula: <IMAGE> with an optionally substituted triazole or tetrazole in the presence of an acid or a complex of the acid in an organic solvent at 0 DEG to 80 DEG C.