| 摘要 |
<p>New technetium [99m] (1) complexes can be used in imaging compositions for example in myocardial imaging. The complexes have one of the following formulae:… <99m>Tc (I) [P(R<1>, R<2>, R<3>)]6<+>A<-> 1… wherein R<1>, R<2> and R<3> are independently selected from the group consisting of lower alkyl, lower alkoxy, and lower alkory-substituted lower alkyl, provided each phosphorus is bonded through at least one oxygen to a carbon; and A<-> is a non-deleterious, chemically suitable, pharmaceutically acceptable anion;… <99m>Tc (I) [P(X. R<1>)]6<+>A<-> 2… wherein X is a bridging substituent selected from the group consisting of lower alkylenedioxy, and lower oxyalkyl; R<1> has the same meaning as set forth above, provided each phosphorus is bonded through at least one oxygen to a carbon, and A<-> has the same meaning as set forth above;… <99m>Tc (I) [PY]6<+>A<-> 3… wherein Y is a trivalent bridging substituent selected from the group consisting of lower tri(oxyalkylene)alkane, lower oxydialkyl, and lower dioxyalkyl, provided each phosphorus is bonded through at least one oxygen to a carbon; and A<-> has the same meaning as set forth above;… <99m>Tc (I) [R<4>, R<5>-P-R<6>-P-R<7>, R<8>]3<+>A<-> 4… wherein R<4>, R<5>, R<7> and R<8> are independently selected from the group consisting of, lower alkyl, lower alkoxy, and lower alkoxy-substituted lower alkyl; R<6> is a linking substituent selected from the group consisting of lower alkylene, oxygen, lower alkylenedioxy and lower oxyalkylene, provided each phosphorus is bonded through at least one oxygen to a carbon; and A<-> has the same meaning as set forth above; and… <99m>Tc (I) [X-P-R<6>-P-X]3<+>A<-> 5… wherein X, R<6> and A<-> have the same meaning as set forth above and provided each phosphorus is bonded through at least one oxygen to a carbon.</p> |
