| 发明名称 |
Production of thrombin inhibitors. |
| 摘要 |
<p>A method for the production and secretion of proteins with hirudin activity in an eukaryotic host organism is provided. There are also provided hybrid vectors comprising a DNA sequence encoding a signal peptide upstream of and in reading frame with the structural gene for desulphatohirudin, and eukaryotic host organisms transformed with said hybrid vectors.</p> |
| 申请公布号 |
EP0225633(A2) |
申请公布日期 |
1987.06.16 |
| 申请号 |
EP19860117098 |
申请日期 |
1986.12.09 |
| 申请人 |
CIBA-GEIGY AG;PLANTORGAN WERK HEINRICH G.E. CHRISTENSEN KG |
发明人 |
MEYHACK, BERND, DR.;MARKI, WALTER, DR.;HEIM, JUTTA, DR. |
| 分类号 |
A61K38/55;A61K38/00;A61P7/02;C07K1/20;C07K1/22;C07K14/00;C07K14/815;C12N1/16;C12N1/19;C12N9/16;C12N9/26;C12N15/00;C12N15/09;C12N15/15;C12N15/70;C12N15/81;C12N15/90;C12P21/00;C12P21/02;C12R1/865 |
主分类号 |
A61K38/55 |
| 代理机构 |
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