| 摘要 |
NEW MATERIAL:A 2-pyridylacetamide derivative expressed by formula I (R<1> is H, 1-15C alkyl, 3-20C alkenyl or 7-15C aralkyl; R<2> is H, straight-chain alkyl, cyclic alkyl, alkenyl, aryl or aralkyl) and pharmacologically acceptable acid addition salt thereof. EXAMPLE:2-Benzylthiocarbomoyl-2-(2-pyridyl)acetamide. USE:A remedy for peptic ulcer having inhibitory action on gastric acid secretion and protecting action on gastric mucosae and low toxicity. PREPARATION:A compound expressed by formula II (R<3> is lower alkyl) is reacted with a compound expressed by the formula H2N-R<1> in water, an organic solvent or a mixed solvent thereof at e.g. room temperature -100 deg.C for 12-24hr to afford the aimed compound expressed by formula I.
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