| 摘要 |
<p>The present invention relates to novel 4 min -demethyl-4-epipodophyllotoxin derivatives of formula …<CHEM>… wherein R1 is an alkyl group; X1 and X2 are each a hydroxyl group or an amino group substituted by one or two alkyls, provided that either one of X1 and X2 is an amino group substituted by one or two alkyls, and the other is a hydroxyl group… and a process for their preparation. The compounds exhibit excellent anti-tumor activities and high water-solubility and can, therefore, be used as medicaments.</p> |
