AZACYCLOALKANE DERIVATIVE

摘要

NEW MATERIAL:An azacycloalkane derivative shown by formula I (R is alkyl; m is 5-7; n is 3-15). EXAMPLE:1-(3-Octyloxypropyl)azacycloheptan-2-one. USE:Useful as an absorption promotor having improved action on permeability and permeation of drug by blending drug with a specific amount of the promotor. The promotor itself has antimicrobial action. Use of the promotor can maintain durability of drug, further adjusts absorption rate of drug and prevents side effects caused by excess administration. The promotor has merits wherein a drug causing liver disorder can be relatively safely administered. PREPARATION:As shown a reaction formula (M is alkali metallic ion and X is halogen, etc.,), a compound shown by formula III obtained from an azacycloalkane-2-one and an alkali catalyst is reacted with an alcohol in the presence of an alkali catalyst to give a compound shown by formula I.