摘要 |
The present invention relates to new furyl derivatives of 16-substituted prostaglandins, to a process for their preparation and to pharmaceutical and veterinary compositions containing them. The new compounds of the invention are optically active or racemic prostaglandins of the following formula (I) <IMAGE> (I) wherein R is (1) -OH or -OR' wherein R' is C1-C6 alkyl optionally substituted by phenyl or by a monocycloalkyl group or by a pentatomic or hexatomic heteromonocyclic ring containing at least one heteroatom chosen from O, S and N; (2) <IMAGE> wherein each of R'' and R''', is independently, hydrogen; C1-C6 alkyl; phenyl; or a pentatomic or hexatomic heteromonocyclic ring containing at least one heteroatom chosen from O, S and N; or R'' and R''', together with the nitrogen atom to which they are linked, form a pentatomic or hexatomic heteromonocyclic ring optionally containing a further heteroatom chosen from O, S and N; (3) -W-(CH2)n-X wherein W is -O- or -NH-, n is an integer of 1 to 4 and X represents a group -OR' or a group <IMAGE> wherein R', R'' and R''' are as defined above; one of R1 and R2 is hydrogen and the other is hydroxy or R1 and R2, taken together, form an oxo group; one of R3 and R4 is hydrogen and the other is hydroxy; one of R5 and R6 is hydroxy and the other is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, or phenyl; one of R7 and R8 is hydrogen and the other is a C1-C4 alkyl or tri-halo-C1-C4 alkyl group; m is an integer of 1 to 3; R9 is a 2-furyl or 3-furyl group, optionally substituted by one or more substituents chosen from C1-C4 alkyl, C1-C4 alkoxy, tri-halo-C1-C4 alkyl and halogen; and the symbol represents a single bond or a cis double bond. |
申请人 |
FARMITALIA CARLO ERBA S.P.A. |
发明人 |
FAUSTINI, FRANCO;PANZERI, ACHILLE;ORZI, FABRIZIO;DI SALLE, ENRICO;CESERANI, ROBERTO |