| 摘要 |
PURPOSE:An ointment base, obtained by blending a hydrogel with a specific methacrylic acid based copolymer and a solubilizing agent in a specific proportion and capable of exhibiting sufficient adhesive and local residence properties for wet surfaces without inhibiting effect of a drug active agent or active ingredient to be blended. CONSTITUTION:An ointment base, obtained by blending (A) a hydrogel formed from a water-soluble high polymer and water or mono- - polyhydric alcohol, (B) dimethylaminothyl methacrylate-methyl methacrylate copolymer or/and ethyl methacrylate-chlorotrimethylammonium ethyl methacrylate copolymer and (C) a solubilizing agent, capable of dissolving the component (B) but incompatible with water and polyhydric alcohol at 1:1-1:25 weight ratio of the ingredients (B) to (C) and suitable for application to wet surfaces, e.g. mucosae, etc. The amounts of the ingredients to be blended are as follows; 0.1-10wt% water-soluble high polymer in the ingredient (A), 0.5-20wt% ingredient (B) and 5-50wt% ingredient (C) based on the total ointment base.
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