| 摘要 |
NEW MATERIAL:A compound of formula I [A is carbonyl, sulfonyl; B is formula II (E is methylene, ethylene, O; dotted lines means additional bond), formula III (F is methylene, ethylene), formula IV (R<1>-R<6> are H, methyl), when A is carbonyl, or B is 1,2-phenylene, when A is sulfonyl; D is ethylene, ethenylene, ethinylene; n is 0-2] or its acid adducts. EXAMPLE:N-[4-[4-( 1,2-Benzisothiazol-3-yl )-1-piperazinyl]butyl]bicyclo[2.2.1]hep tane-2,3-di-oxo-carboxyimide. USE:A remedy for central nervous diseases. It exerts very weak side-effects on the out-vertebra system. PREPARATION:For example, the condensation reaction of a compound of formula V with an amino derivative of formula VI is carried out in an inert solvent to give the compound of formula I. |
