| 摘要 |
NEW MATERIAL:A 2-iodobutyrophenone derivative of formula I [X is radioactive or non-radioactive iodine atom; R is group of formula II or III (R1 is H, halogen, alkyl, haloalkyl or alkoxy; R2 is H or alkyl; the dotted line is single or double bond)]. EXAMPLE:4'-Fluoro-2'-iodo-4-( 4-hydroxy-4-p-chlorophenylpiperidin-o )-butyrophenone (2-iodohalopellidole). USE:A dopamine receptor orienting radioactive diagnostics or radioactive drugs. A remedy for psychosis, analgesic, hypotensor, ataractic and tranquillizer. PREPARATION:The compound of formula I can be produced e.g. by diazotizing a 2-aminobutyrophenone derivative of formula IV and reacting the resultant diazo compound of formula V (Y<-> is halogen ion or HSO4<->) with a radioactive or non-radioactive metal iodide. |
