Pyrrolidinylamide ester derivative having anti-prolyl endopeptidase activity, its synthesis and use and a pharmaceutical composition containing it.

摘要

A novel pyrrolidinylamide ester derivative that exhibits inhibitory activity against prolyl endopeptidase, methods for synthesis thereof and its use in a pharmaceutical composition as an inhibitor against said enzyme are disclosed. The pyrrolidinylamide ester of the invention has the following general formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="23" wi="76" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry> wherein n is 0 or an integer of l to 7 and R is hydrogen atom or a straight or branched alkyl having l to 8 carbon atoms.