| 摘要 |
NEW MATERIAL:A compound expressed by formula I [Z is S or O; R<1> is H, lower alkyl or phenyl which may have a substituent group, e.g. halogen, etc.; R<2> is H, lower alkyl, cycloalkyl which may have lower alkyl, (CH2)mNR<3>R<4> or (CH2)nAr; R<3> and R<4> are lower alkyl or heterocyclic ring which may contain further O as a hetero atom in NR<3>R<4>; m is 2 or 3; Ar is pyridyl or phenyl which may have a substituent group, e.g. halogen, etc.; n is 0, 1 or 2; X is H, halogen or lower alkoxy] and an acid addition salt thereof. EXAMPLE:5-Methyl-5-(4-chlorophenyl)-2-[ 2-(2-pyridyl)ethylimino ]-3,4,5,6-tetrahy dro-1H-1,3-thiazine. USE:A remedy for cardiopathy (increasing agent for coronary blood stream, cardiotonic agent, anti-inflammatory agent or diuretic agent). PREPARATION:A compound expressed by formula II is reacted with a compound expressed by the formula R<2>NCS to give a compound expressed by formula III, which is cyclized to afford the aimed compound expressed by formula I. |
