| 发明名称 |
FOERFARANDE OCH MELLANPRODUKTER FOER FRAMSTAELLNING AV 3,3'-AZO-BIS-(6-HYDROXIBENSOESYRA). |
| 摘要 |
A method of preparing 3,3'-azo-bis-(6-hydroxy benzoic acid) of formula I <IMAGE> I and salts thereof in at least 98% purity for treating inflammatory intestinal diseases. According to the invention a compound II <IMAGE> II is diazotized, and the diazonium salt obtained is coupled with a compound III <IMAGE> III The formed intermediate IV, which is also comprised by the invention, <IMAGE> IV is hydrolized in alkaline medium to form the compound I. R1, R2 and R3 signify lower alkyl, R2 also possibly substituted phenyl. |
| 申请公布号 |
FI73201(B) |
申请公布日期 |
1987.05.29 |
| 申请号 |
FI19810000928 |
申请日期 |
1981.03.25 |
| 申请人 |
PHARMACIA AB |
发明人 |
AGBACK, KARL HUBERT;NYGREN, ALF SIGURD |
| 分类号 |
A61K31/19;A61K31/655;A61P1/00;A61P1/04;C07C67/00;C07C241/00;C07C245/08;C07C301/00;C07C303/30;C07C309/04;C07C309/29;C07C309/66;C07C309/73;C09B29/14;C09B43/24;(IPC1-7):C07C107/06 |
主分类号 |
A61K31/19 |
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