N-SUBSTITUTED DIPHENYLPIPERIDINES

摘要

Compounds of the formula I wherein R1 is the asterisk denotes the specific bonding orientation to the piperidine moiety; R2 is alkylene or -CO-(CH2)n- wherein n is 0 to 11; R3 and R4, independently, are hydrogen, halogen or lower alkoxy; and HET is pyridinyl, pyrimidinyl or imidazolyl, and salts thereof with pharmaceutically acceptable acids, are described. The compounds of formula I exhibit insulin lowering activity and are useful as antiobesity agents.