| 摘要 |
PURPOSE:To obtain the titled compound useful as an intermediate for pharmaceuticals, in high yield and purity, by catalytically reducing N-methyl-2(or 7)-homopiperazinone in the presence of a dioxane solvent using a specific catalyst and cooling the reaction system immediately after the completion of reduction. CONSTITUTION:N-methyl-2(or 7)-homopiperazinone is used as a raw material and subjected to catalytic reduction usually at 100-350 deg.C, preferably 150-300 deg.C under 5-500kg/cm<2>, preferably 30-150kg/cm<2> pressure in a dioxane solvent in the presence of a copper-chromium catalyst. Immediately after the completion of the reduction, the reaction system is cooled to obtain the objective compound. The cooling is carried out e.g. by using a continuous reduction reactor, by taking the reaction system out of a batch autoclave reactor in the form of vapor or liquid, etc., immediately after the reduction, etc. A commercially available low-cost copper-chromium catalyst can be used as it is as the above catalyst.
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