| 摘要 |
NEW MATERIAL:A compound expressed by formula I (R<1> is amoinocarbonyl; R<2> is H or tert-butyloxycarbonyl; R<3> is H or two R<3> groups together form isopropylidene, provided that R<1> will not represent L-alanyl). EXAMPLE:N<6>-tert-Butyloxycarbonyl-2-chloro-9-[5'-O-(N-tertbut yloxycarbonyl-L- phenylalanyl)sulfamoyl-beta-D-ribofuranosyl]adenine. USE:A carcinostatic agent. PREPARATION:A compound expressed by formula II, e.g. N<6>-tert-butyloxycarbonyl-2-chloro-9-(2',3'-O-isopropylidene-5'-O-sul famoyl-beta-D-ribofurano syl)adenine, is reacted with di-tert-butyl dicarbonate to give a compound expressed by formula III, which is then reacted with an active ester of an aminocarboxylic acid (without including L-alanine).
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