| 摘要 |
PURPOSE:To provide an immuno-suppressor containing a specific isoflavone compound as an active component, having low toxicity and excellent immuno- suppressing activity and useful for the remedy and the prevention of relapse of autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, etc. CONSTITUTION:The isoflavone compound of formula (R<1> is OH or methoxy; R<2> is H, carboxyl or ethoxycarbonyl) is used as an immuno-suppressing agent. Concrete examples of the compound are 5,7,4'-trihydroxyisoflavone, 5,7- dihydroxy-4'-methoxyisoflavone-2-carboxylic acid, etc. The compound of formula has excellent immuno-suppressing activity and is useful for the remedy and prevention of relapse of human autoimmune diseases such as chronic active hepatitis, osteoporosis, etc. It is administered orally or parenterally at a dose of usually 200-1,000mg/day.
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