| 摘要 |
PURPOSE:An antihepatitic agent that contains, as an active ingredient, 3-(3- methyl-2-butenyl)-4-hydroxybenzoic acid which is easily derived from the basic skeleton of a component in a Chinese medicine, Artemisia capillaris, thus having antihepatitic action as well as cholagogue and antitumor actions. CONSTITUTION:The objective antihepatic agent is obtained by using 3-(3- methyl-2-butenyl)-4-hydroxybenzoic acid of formula I, as an active ingrdient. The compound of formula I manifests a therapeutic effect for hepatic disorders caused by chemicals such as carbon tetrachloride or ethanol. Further, it promotes the secretion of bile and additionally has antitumor action. The compound of formula I is easily synthesized from 4-hydroxybenzoic acid of formula II.
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