| 摘要 |
PURPOSE:To obtain the titled substance inexpensively, in high purity and in high yield, by reacting a 6-methoxy-2-acetylnaphthalene with a phenyldimethylsulfonium methyl sulfate in the presence of an alkyl hydroxide. CONSTITUTION:A compound shown by the formula I is reacted with a phenyldimethylsulfonium methyl sulfate shown by the formula II in the presence of an alkali hydroxide(preferably powdery NaOH, etc.,) at 15-55 deg.C, to give a compound shown by the formula III. The reaction is carried out in a solvent immiscible with water(e.g., halogenated hydrocarbon or hydrocarbon), a reaction mixture is washed with water, fractionated and the solvent, thioanisole and the aimed substance are recovered. The compound shown by the formula II is obtained by reacting thioanisole with a sulfuric diester at 80-110 deg.C and can be used for the reaction without isolating it. USE:An intermediate for synthesizing 2-(6-methoxy-2-naphthyl)propionic acid having improved anti-inflammatory action, analgesic action and antipyretic action.
|
