Peptide derivatives, the preparation and their use as elastase inhibitors

摘要

Lipopeptides of the formula, R-X-(P1)x-(L-Ala-L-Ala-P2-A wherein x is 0 or 1, R is the acyl residue of a hydrophobic carboxylic acid, P2 is, for instance, L-Ala, L-Val, L-Pro-L-Ala or L-Pro-L-Val, P1 is a residue of an amino acid or an oligopeptide formed from 2-8 amino acids, X represent a divalent group or a direct covalent bond and A represents the C-terminal portion (modified or not) of -(P1)x-(Ala-Ala-P2). These lipopeptides can be used as elastase inhibitors.