| 摘要 |
PURPOSE:A skin cosmetic, obtained by incorporating at least one tetrapeptide in a skin cosmetic base and having improved humectant and skin beautifying effect, etc. CONSTITUTION:A skin cosmetic, obtained by incorporating at least one tetrapeptide expressed by the formula (Arg is arginine; Pro is proline; Phe is phenylalanine; n is 1-3; - is peptide bond) in a skin cosmetic base and having skin roughening improving, keratin improving and skin beautifying effect, etc. Mono- - trimers of the tetrapeptide are obtained by initially coupling phenylalanine to proline, eliminating N-terminal protecting group from the resultant product, further coupling the resultant product with arginine, eliminating the N-terminal protecting group from the product, hydrogenating the product and eliminating the C-terminal protecting group. |
