| 摘要 |
The present invention relates to A medical device for the pulsatile administration of a drug through intact skin at a first steady state flux during a first delivery period and a second steady state flux during a second delivery period, said first flux being substantially higher than said second flux; said first and second delivery periods comprising a substantial portion of a predetermined administration period, characterised in that said device comprises:… a) a reservoir of said drug containing an amount of drug sufficient to adminster drug at said first and second steady state fluxes throughout said administration period;… b) a reservoir of a skin permeation enhancer for said drug; said reservoir containing an amount of said permeation enhancer sufficient to permit administration of said drug at said first flux only through said first delivery period; and… c) means for maintaining said device on the skin in drug and permeation enhancer transferring relationship thereto. |
