| 摘要 |
A porphyrin compound of the formula: <IMAGE> (I) wherein R1 and R2 are each -CH=CH2, -CH2CH3, -CH(O-lower alkanoyl)CH3, -CH(OR)CH3 or -CH(O-lower alkylene-OR)CH3; R3 is -H, -COOH, -COO-lower alkyl, -COO-lower alkylene-OR or -COO-lower alkylene-OOC-Z; R4 is -H, -lower alkyl or -lower alkylene-OR; R is -H, -lower alkyl or a residue of a polyfunctional carboxyl compound excluding a hydrogen atom therefrom; Z is a residue of the compound of the formula (I) excluding R3 therefrom; A is -CH2- or -CO-; and the dotted line from the gamma-position indicates no bonding or a single direct bond; and the dotted line between the 7- and 8-positions indicates the presence of a single bond or a double bond; and its complexes with a metal(s) in the porphine skeleton and/or at the residue of the polyfuntional carboxyl compound, at least one of R1, R2, R3 and R4 being a group containing R which represents the residue of the polyfunctional carboxyl compound and R1 being capable of representing 1-iodoethyl in addition to said meanings when R3 is -COO-lower alkylene-OOC-Z, which shows a high accumulation in the locus of cancer with quick excretion from normal tissues. |
