发明名称 |
METHOD OF PRODUCING 7-AMINO-3-SUBSTITUTED METHYL-DELTA-3-CEPHEM-4-CARBONIC ACID OR ITS ACID-ADDITIVE SALTS |
摘要 |
PURPOSE:To obtain the titled compound useful as an intermediate for an antibacterial agent in high purity in high yield easily, by reacting a specific cephalosporanic acid with a triazole or tetrazole in an organic solvent in the presence of an acid or a complex of an acid. CONSTITUTION:A compound shown by the formulaI[R<1> is H or alkoxy; R<2> is NH2, or a group shown by the formula II or III (R<3>-R<7> are organic residue not participating in a reaction); X is optionally substituted acyloxy or carbamoyloxy; Y is S, or S O], derivative at its COOH, or its salt, is reacted with a triazole or tetrazole wherein C in the ring may be substituted, to give a compound shown by the formula IV, its derivative, or its salt. The reaction is carried out in an organic solvent, e.g., nitromethane, etc. in the presence of an acid or a complex of acid (e.g., sulfuric acid, BF3 or its complex compound etc.). |
申请公布号 |
SU1308198(A3) |
申请公布日期 |
1987.04.30 |
申请号 |
SU19823520352 |
申请日期 |
1982.12.09 |
申请人 |
TOYAMA CHEMICAL CO,JP |
发明人 |
HIROSHI SADAKI,JP;HIROKAZU NARITA,JP;HIROYUKI IMAIZUMI,JP;YOSHINORI KONISHI,JP;TAKIKHIRO INABA,JP;TATSUO HIRAKAWA,JP;HIDEO TAKI,JP;MASARU TAI,JP;YASUO WATANABE,JP;ISAMU SAIKAWA,JP |
分类号 |
C07D501/04;A61K31/545;A61K31/546;C07D501/16;C07D501/18;C07D501/24;C07D501/38;C07D501/46 |
主分类号 |
C07D501/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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