Benzimidazoles, benzoxazoles, benzothiazoles and their production, formulation and use as gastric acid secretion inhibitors.

摘要

There are described compounds of formula I.
<Chemistry id="chema01" num="0001"><Image id="ia01" he="30" wi="83" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>in which A is a benzene or heterocyclic ring,
<UnorderedLists id="ula01" listStyle="none"><ListItem>y is 0 or 1,</ListItem><ListItem>L is a group containing 1 or 2 carbon atoms, or is a single bond,</ListItem><ListItem>R<Sub>9</Sub> and R<Sub>10</Sub> have a variety of significances, eg</ListItem><ListItem>R<Sub>10</Sub> may form part of a double bond with L, or</ListItem><ListItem>the group -NR<Sub>9</Sub>R<Sub>10</Sub> forms a ring carrying substituents R<Sub>1</Sub> to R<Sub>8</Sub>.</ListItem><ListItem>or</ListItem><ListItem>when L is a single bond -NR<Sub>10</Sub> and Re may form a ring carrying substituents R<Sub>16</Sub> to R<Sub>25</Sub>, or</ListItem><ListItem>the group -LNR<Sub>9</Sub>R<Sub>10</Sub> forms a heterocyclic ring carrying substituents R<Sub>26</Sub> to R<Sub>33</Sub>,</ListItem><ListItem>R<Sub>1</Sub> to R<Sub>8</Sub> and R<Sub>16</Sub> to R<Sub>33</Sub> have a variety of significances</ListItem><ListItem>n is 0, 1 or 2,</ListItem><ListItem>x is 3, 4 or 5,</ListItem><ListItem>X is S, O or NR<Sub>15</Sub>,</ListItem><ListItem>R<Sub>15</Sub> is hydrogen, -COR, -COOR or alkyl optionally substituted by -OCOR,</ListItem><ListItem>and certain provisos.</ListItem></UnorderedLists>

Processes for making the compounds and pharmaceutical formulations containing them, eg for the treatment of conditions involving excess gastric acid secretion, are also described.