| 摘要 |
<p>PCT No. PCT/AU86/00386 Sec. 371 Date Aug. 25, 1987 Sec. 102(e) Date Aug. 25, 1987 PCT Filed Dec. 18, 1986 PCT Pub. No. WO87/03882 PCT Pub. Date Jul. 2, 1987.DNA molecules comprising artificially constructed polynucleotide sequences substantially coresponding to all or a portion of the base sequence coding for an antigen of Plasmodium faliciparum selected from the group consisting of the Acidic Basic Repeat Antigen Rhoptry (ABRA), the antigen of any of clones Ag 169, Ag303, Ag358, Ag361, Ag372, Ag394 or Ag501, defined herein, and other antigens of P. falciparum cross-reactive therewith. Such DNA molecules are capable of being expressed as polypeptide(s). Synthetic peptides or polypeptides displaying the antigenicity of all or a portion of the above antigens of P. falciparum. Compositions for stimulating immune responses against P. falciparum antigens in a mammal, comprising at least one polyupeptide displaying the antigenicity of the above antigens of P. falciparum, together with a pharmaceutically acceptable carrier therefor.</p> |
