PROCESS FOR PREPARING 1,2-DIHYDRO-3H-PYRROLO/1,2-A/ PYRROLE-1-CARBOXYLIC ACID NITRILES

摘要

A process for 5-aroylation of 1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole-1-carboxylic esters and nitriles by reacting a pyrrolo pyrrole …… with an aroyl morpholide …… and an inorganic acid chloride in an inert aprotic solvent; followed by treatment with weak or strong base to form: …… The nitrile (V) can be hydrolyzed to the acid (III).