PIPERAZINE DERIVATIVE, MANUFACTURE AND HYPOTENSIVE COMPOSITION

摘要

The invention relates to new piperazine derivatives of the formula …… wherein A is an optionally substituted bicyclic hetero aryl radical, n has the value 1 or 2, R1 and R2 are hydrogen or alkyl (1-3C).… A is -CH2-CH2- or -CH(CH3)-CH2- and B is an optionally substituted aryl or hetero aryl group, an alkyl group or a saturated or partly unsaturated cycloalkyl group and salts and products thereof. These new compounds are useful for the treatment of circulatory diseases. In particular it has has been found that these compounds have blood-pressure lowering properties regulated by a central mechanism of action. …The invention also relates to new intermediates useful for the preparation of piperazine compounds of the above formula (1).