| 发明名称 |
NOVEL ERGOLENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME |
| 摘要 |
The invention relates to novel 2-halogenated 8- and 1,8-substituted ergolene derivatives of the formula (I) and the acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the formula (I) <IMAGE> (I) wherein X stands for a halogen; R stands for a C1-4 alkyl group and R'' means a hydroxyl group; or R stands for an acyl or substituted acyl group and R'' represents a halogen or an -OR' group, wherein R' stands for an acyl or substituted acyl group; or R stands for hydrogen and R'' means a halogen or an -OR' group, wherein R' stands for an acyl or substituted acyl group; and the dotted line means a double bond between the 8-9 or 9-10 positions. The compounds of the formula (I) possess an antipsychotic and antihypoxic action and a negligable extrapyramidal side-effect. |
| 申请公布号 |
SE8701700(D0) |
申请公布日期 |
1987.04.24 |
| 申请号 |
SE19870001700 |
申请日期 |
1987.04.24 |
| 申请人 |
RICHTER GEDEON VEGYESZETI GYAR RT |
发明人 |
1)T * KEVE;2)G * MEGYERI;3)B * STEFKO;4)L * KOVACS;5)A * KASSAI;6)B * KISS;7)I * LASZLOVSZKY;8)E * LAPIS;9)E * PALOSI;10)D * GROO;11)L * SZPORNY |
| 分类号 |
A61K31/48;A61P9/00;A61P25/18;C07D457/02;(IPC1-7):C07D/ |
主分类号 |
A61K31/48 |
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