摘要 |
Pharmaceutical compositions in which the drug delivery system permits selective targeting take advantage of the amphipathic helices of apolipoproteins or binding regions of apolipoproteins for LDL receptors or both. In one embodiment, the LDL receptor binding region of an apolipoprotein, in particular apoB or apoE is covalently bound to either an active ingredient per se or to a carrier for the active ingredient. This delivery system specifically targets tissues which bear the LDL receptor. In another embodiment, the amphipathic alpha helices normally associated often with apolipoproteins are conjugated to proteins which target specific tissues such as immunoglobulins or, preferably, the LDL receptor binding protein regions. This fused system is then associated with an active ingredient or an intermediate carrier therefor. The drug delivery systems described provide novel targeting systems for homing active ingredients to specific tissues. |