NAPHTHALENESULFONAMIDE DERIVATIVE

摘要

NEW MATERIAL:The naphthalenesulfonamide derivative of formula I (n is 2 or 3; X is H or halogen) and its acid addition salt. EXAMPLE:1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-azepine. USE:Useful as a remedy for circulatory diseases. It has excellent effect to relax smooth muscle and increase blood flow rate and is useful as a vasodilator, hypotensor, cerebral circulation improver, remedy for stenocardia, remedy for cerebrocardial diseases and preventive and remedy for thrombus of cerebrocardiovascular system. PREPARATION:The compound of formula I can be produced by reacting the sulfonic acid halogenide derivative of formula II (A is halogen) with the amine derivative of formula III in an organic solvent such as chloroform at a temperature between 0 deg.C and the refluxing temperature of the reaction solvent. The amount of the compound of formula III is preferably 3-5 equivalent per 1 equivalent of the compound of formula II.