发明名称 |
COMPOSITIONS FOR TREATING GLAUCOMA |
摘要 |
A method for the treatment of glaucoma or lowering intraocular pressure in a mammal, involving topically administering to the eye of such mammal a selectively metabolized beta-blocking compound of the formula <IMAGE> wherein R may be lower alkyl, lower hydroxyalkyl, lower alkynyl, aralkyl, or an ester-containing group and Ar may be substituted or unsubstituted aromatic; or a pharmaceutically acceptable salt thereof. Because of a relatively long duration of action of such compounds in ocular fluids and a relatively short duration of action in the systemic circulation, such compounds are useful for the treatment of excessive intraocular pressure without substantial systemic effects. |
申请公布号 |
EP0081580(B1) |
申请公布日期 |
1987.04.22 |
申请号 |
EP19820902332 |
申请日期 |
1982.06.23 |
申请人 |
AMERICAN HOSPITAL SUPPLY CORPORATION |
发明人 |
MATIER, WILLIAM LESLEY;KAM, SHEUNG-TSAM |
分类号 |
C07C219/14;A61K31/235;A61K31/24;A61P27/02;A61P27/06;C07C;C07C67/00;C07C69/76;C07C69/78;C07C69/88;C07C213/00 |
主分类号 |
C07C219/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|