发明名称 |
Process for the preparation of 6-demethyl-6-deoxy-6-methylene-5-oxytetracyclin and the 11A-chloro-derivative thereof |
摘要 |
The invention relates to a new and improved process for the preparation of 6-demethyl-6-deoxy-6-methylene-5-oxytetracycline and the 11a-chloro derivative thereof by dehydrating 11a-chloro-5-oxytetracycline-6,12-hemiketal, which comprises treating 11a-chloro-5-oxytetracycline-6,12-hemiketal or an acid salt thereof with a dehydrating mixture formed by the reaction of chloro sulfonic acid and formic acid and isolating the 11a-chloro-6-demethyl-6-deoxy-6-methylene-5-oxytetracycline and salt thus obtained and optionally dehalogenating the same by reaction with a reducing agent. The advantage of the process of the present invention is that it is simple, economical and suitable for industrial scale manufacture and provides a pure product of high quality by excellent yields.
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申请公布号 |
US4659515(A) |
申请公布日期 |
1987.04.21 |
申请号 |
US19840646574 |
申请日期 |
1984.08.31 |
申请人 |
CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT |
发明人 |
LUGOSI, GYOERGY;HIMA NEE TOTH, MARIA;BAKONYI, MARIA;SZOKE, SANDOR |
分类号 |
C07C231/00;C07C67/00;C07C231/12;C07C233/00;C07C237/26;C07C309/73;(IPC1-7):C07C103/19 |
主分类号 |
C07C231/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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