| 摘要 |
PURPOSE:To prepare-4-methylimidazole in high purity in high yield, by reacting methylglyoxal with ammonium oxalate and formaldehyde by the use of a specific amount of water in a water medium. CONSTITUTION:By the use of 4-30 times, especially 5-15 times as much water as methylglyoxal of raw material, methylglyoxal is added to an aqueous solution of ammonium oxalate and formaldehyde, or a mixed solution of methlylyaxal and formaldehyde is added to an aqueous solution of ammonium oxalate, or methylglyoxal and formaldehyde are simultaneously added to it, or the mixed solution of methylglyoxal and formaldehyde and ammonium oxalate are simultaneously added to water previously prepared, or three raw materials are simultaneously added to the water, and the reaction is carried out to give 4-methylimidazole. EFFECT:Low-grade methylglyoxal may be used.
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