| 摘要 |
<p>23986-109 Disclosed are novel bis-dioxopiperazine derivatives, process for their preparation, antitumor agents comprising them and compositions containing them. The bis-dioxopiperazine derivatives are represented by the following general formula (I): (I) wherein R1 represents a hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms; R2 represents a hydrogen atom or a group of ; R3 and R4, which are respectively independent and are the same or different, represent respectively a lower alkyl group having 1 to 4 carbon atoms, a cycloalkyl group having 3 to 7 carbon atoms or a heterocyclic radical selected from the group consisting of substituted or unsubstituted piperidino, substituted or unsubstituted piperazino, substituted or unsubstituted morpholino and substituted or unsubstituted thiomorpholino, or R3 and R4 are bonded together to form d group of which represents a cyclic amino group selected from the group consisting of substituted or unsubstituted pyrrolidino, substituted or unsubstituted piperazino, substituted or unsubstituted morpholino, substituted or unsubstituted thiomorpholino and substituted or unsubstituted thiadiazino; and the substituents of the heterocyclic radical and the cyclic amino group are selected from the group consisting of a lower alkyl group Case 551 having 1 to 4 carbon atoms, oxo and phenyl, said cyclic amino group being not morpholino when R1 is a hydrogen atom and R2 is the group of .</p> |
