| 摘要 |
<p>PURPOSE:To obtain the titled compound useful as an agent to inhibit the proliferation of DNA virus and RNA virus, under mild condition, by reacting imidazole nucleoside with a metal alcoholate in an alcohol solvent, and treating the reaction product with ammonia. CONSTITUTION:The objective compound of formula II can be produced by (1) reacting the imidazole nucleoside of formula I (R<1> is lower alkyl; R<2>-R<4> are H or protecting group) with a metal alcoholate (e.g. sodium methoxide) in an alcohol solvent usually at room temperature to activate the 5-nitrile group to iminoether group, and (2) treating the reaction product with ammonia.</p> |
