| 摘要 |
Prostacyclin, although having a useful dilating effect on blood vessels, is not sufficiently stable to ensure successful use as a hypotensive agent. A 7-oxopro-stacyclin derivative of the general formula in which R3 represents a hydrogen atom, a straight-chain or branched-chain alkyl radical having from 1 to 4 carbon atoms, or a C1-C4-alkoxyalkyl radical, W represents a group, the hydroxy group of which may be free or substituted by a C1-C4-alkanoyl group or a tetrahydropyranyl group and may be in the ?- or .beta.-position, R2 represents a straight-chain or branched-chain halogen-substituted alkyl group having from 3 to 7 carbon atoms, a straight-chain or branched-chain alkenyl radical having from 3 to 7 carbon atoms which can be substituted by fluoro, chloro or a C1-C4-alkyl group, or a straight-chain or branched-chain alkynyl radical having from 2 to 6 carbon atoms which may be substituted in the 1position by fluorine or C1-C4-alkyl, and R5 represents a hydroxy group or a tetrahydropyranyl group or a pharmaceutically acceptable salt thereof has proved to have not only a hypotensive and bronchodilative action, for example, but also an increased stability over prostacyclin. Advantages in medicinal use over other prostaglandins have also been found. |
