| 摘要 |
<p>Granulocyte-macrophage colony stimulating factor-like polypeptides having a specific activity of at least 1 x 108 Units/mg and methods of making these products. DNA sequences and recombinant DNA molecules and microbial hosts transformed with them which produce human granulocyte-macrophage colony stimulating factor-like polypeptides in high yields, and methods of making these polypeptides. The human granulocyte-macrophage colony stimulating factor-like polypeptides of this invention may be used to treat cancer patients to regenerate leukocytes after radiation or chemotherapy treatment, and to increase white blood cell count to reduce the likelihood of viral, bacterial, fungal, and parasitic infection, especially in immunologically compromised patients such as these suffering from AIDS.</p> |
