发明名称 |
PROCESS FOR PROSTAGLANDIN E1, PRODUCTION AND NOVEL DELTA 7-PROSTAGLANDINES E AND 7-HYDROXYPROSTAGLANDINS E |
摘要 |
The present invention provides an industrially very advantageous process for producing prostaglandins E1 with fewer steps and in higher yield. The process comprises reacting a 7-hydroxyprostaglandin E with a reactive derivative of an organic sulfonic acid in the presence of a basic compound to form the corresponding 7-organic sulfonyloxyprostaglandin E, treating the resulting 7-organic sulfonyloxyprostaglandin E, after or without isolation, in the presence of a basic compound to form a DELTA 7 -prostaglandin E, thereafter selectively reducing the carbon-carbon unsaturated bond existing on the alpha -chain. Some of the 7-hydroxyprostaglandins E and DELTA 7-prostaglandins E used in the process are novel compounds. |
申请公布号 |
DE3275542(D1) |
申请公布日期 |
1987.04.09 |
申请号 |
DE19823275542 |
申请日期 |
1982.11.05 |
申请人 |
TEIJIN LIMITED |
发明人 |
NOYORI, RYOJI;SUZUKI, MASAAKI;KUROZUMI, SEIZI;KAWAGISHI, TOSHIO |
分类号 |
C07C405/00;(IPC1-7):C07C177/00;A61K31/557 |
主分类号 |
C07C405/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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