| 摘要 |
NEW MATERIAL:A compound expressed by the formula (R<1>-R<3> represent H, optionally substituted alkyl, aryl, etc., or both R<1> and R<2> or both R<2> and R<3> may link together to form an optionally substituted alkylene bridge optionally having 1 - several O, S or N's; R<4> represents hydroxyl, amino, hydroxyamino, optionally substituted alkyloxy, aralkyloxy, alkylamino, sulfonylamino, etc.). EXAMPLE:N-Ethoxycarbonyl-L-isoleucyl-L-prolyl-L-proline. USE:A hypotensor industrially and readily available by a simple synthetic process. PREPARATION:For example, benzyl L-isoleucyl-L-prolyl-L-prolinate hydrochloride and ethyl chloroformate are dissolved in methylene chloride and cooled at -30 deg.C. N-Methylmorpholine is added thereto while stirring and reacted therewith at room temperature for 5hr. |
