REACTIVE PERMITTING A DOSE OF VERY HIGH SENSITIVITY OF THE CHARACTERISTIC ANTIGEN OF THE HEPATITE B VIRUS IN HUMAN BIOLOGICAL LIQUIDS

摘要

The present invention relates to polyfunctional hydrophilic spherical microparticles of uniform size which contain from 5 to 95% of units originating from the copolymerization of an aldehyde of the formula R1 being an alkyl radical, from 5 to 90% of units originating from the copolymerization of an acrylic acid ester of the formula in which R2 is H or alkyl and R3 is a hydroxyalkyl group, less than 15% of units originating from an acrylic acid derivative chosen from amongst R4, R5 and R6 being alkyl radicals, and from 0.1 to 10% of units originating from a crosslinking product. The invention also relates to a process for the preparation of the said microparticles and to the use of these microparticles for the nephelometric determination of HBs antigen.