| 摘要 |
<p>The new indole derivatives of the formula <IMAGE> in which R1 and R2 are identical or different and denote hydrogen or lower alkyl, R3 denotes hydrogen, lower alkyl or halogen and R4 and R5 are identical or different and denote hydrogen, lower alkyl or optionally substituted aryl, and R4 and R5 can also represent lower alkenyl, and wherein R2 and R5 can be linked by an alkylene bridge of the formula -CH2-CH2-CH2)n in which n represents the number 0 or 1, can be prepared by reacting an ammonium or phosphonium salt of the corresponding indolecarboxylic acid with a haloacetic acid allyl ester. The new compounds can be used to prepare acemetacin. The new indole derivatives possess a pharmacological action.</p> |
