摘要 |
<p>N-(Mono- or disubstituted methyl)-2-azetidinones, produced by cyclizing 9-hydroxy or a-halo substituted acid sec-amides in which the amide nitrogen is subsituted with a mono- or di-substituted methyl group having activating substituents, are useful intermediates for the production of antibiotics. The compounds have the formula <CHEM> in which R is hydrogen, C1-C4 alkoxy, amino, protected-amino, acylamino, diacylamino, C1-C4 alkyl, or C1-C4 alkyl sustituted by hydroxy, C1-C4 alkoxy, halogen, amino, protected-amino, carboxy, or protected carboxy; R1 is hydrogen, hydroxy, C1-C4 alkoxy, halogen, or C1-C4 alkyl; R2 is hydrogen, phenyl, substituted phenyl, carboxy, C1-C4 alkoxycarbonyl, protected carboxy, sulfvdryl, C1-C4 alkylthio, C2-C4 alkanoylthio, halogen, C1-C4 alkoxy, C1-C4 alkyl, or C1-C4 alkyl substituted by hydroxy, C1-C4 alkoxy, halogen, amino, protected amino, carboxy, or protected carboxy; Y is a substituted methyl group of the formulae <CHEM> in which R3 or R3 min is hydrogen, C1-C4 alkoxycarbonyl, protected carboxy, carboxy, C1-C4 alkylsulfonyl, arylsulfonyl, C1-C4 alkylsulfinyl, arylsulfinyl, C1-C4 alkanoyl, aroyl, C1-C4 alkyl, cyano, vinyl, or ethinyl; R4 is hydrogen, C1-C4 alkyl, or a carboxy protecting group; R5 and R5 min , independently are C1-C4 alkyl, C1-C4 alkoxycarbonyl, carboxy, protected-carboxy, or phenyl; and, R6 is hydrogen, C1-C4 alkyl, C1-C4 alkoxy-carbonyl, protected-carboxy, or phenyl; or an addition salt thereof.</p> |