| 摘要 |
<p>Phosphoramidite compounds of the general formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="20" wi="62" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein each of R, and R<Sub>2 </Sub>represents a hydroxyl group having a protective group, or the group -OR<Sub>4</Sub>, R<Sub>3</Sub> represents a hydrogen atom, a hydroxyl group having a protective group, or the group -OR<Sub>4</Sub>, R<Sub>4</Sub> represents the group
<Chemistry id="chema02" num="0002"><Image id="ia02" he="13" wi="25" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>X represents a secondary amino group, R<Sub>5</Sub> represents an allylic residue or a protective group capable of being split off by beta-cleavage, and B<Sup>AOC</Sup> represents a nucleoside base residue in which the amino or imino group is protected with an allyloxycarbonyl-type residue, with the proviso that only one of R,, R<Sub>2</Sub> and R<Sub>3</Sub> represents the group-OR<Sub>4</Sub>. The compounds can be produced by reacting a nucleoside represented by the general formula
<Chemistry id="chema03" num="0003"><Image id="ia03" he="23" wi="37" file="IMGA0003.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein each of R'<Sub>1</Sub> and R'<Sub>2</Sub> cepresents a hydroxyl group which may have a protective group, R'<Sub>3</Sub> represents a hydrogen atom, or a hydroxyl group which may have a protective group, and B<Sup>AOC</Sup> is as defined, with the proviso that only one of R'<Sub>1</Sub>, R'<Sub>2</Sub> and R'<Sub>3 </Sub>is a hydroxyl group, with a phosphoramide compound represented by the general formula
<Chemistry id="chema04" num="0004"><Image id="ia04" he="12" wi="22" file="IMGA0004.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein X and R<Sub>5</Sub> are as defined, and Y represents a secondary amino group or a halogen atom.</p> |
