| 摘要 |
NEW MATERIAL:A compound shown by the formula I [R<1> is lower alkyl, cycloalkyl, fluoroethyl, etc.,; R<2>-R<13> is H, lower alkyl and R<11> is further benzyl, etc., Y is Nor CX<2>; X<1> and X<2> are H or halogen and X<2> and R<1> form OCH2(CH3), etc.,; k, o and q are 1 or 2; l is 1 or 2; m is zero O or 1; n and p are 0-3 a=integer with the proviso that o, p and q are not O simultaneously), its acid addition salt, alkali salt and hydrate. EXAMPLE:8-Chloro-1-cyclopropyl-6-fluoro-7-[3-(2-fluoroethyl aminomethyl-1-pyr rolidinyl]-1,4-dihydro-4-oxo-3-quinolinecarbo-xylic acid. USE:An antibacterial agent useful as a low-toxic drug or agricultural chemical showing strong antibacterial action not only on aerobic Gram-negative bacteria, but also on Gram-positive bacteria, anaerobic bacteria and mycoplasma and improved oral absorption properties. PREPARATION:A compound shown by the formula II(Z is reactive eliminable group) is condensed with a compound shown by the formula III and optionally hydrolyzed to give a compound shown by the formula I. |
