发明名称 |
PROCESS FOR PRODUCING OF CEFEM COMPOUNDS |
摘要 |
<p>A process for the manufacture of a cephalosporin derivative of the formula I: <CHEM> in which X is sulphur, oxygen or sulphinyl; R<1> is any one of the C-3 substituents from antibacterially-active cephalosporins known in the art; R<2> is hydrogen or 1-6C alkyl; R<3> is hydrogen or 1-6C alkyl; and the pharmaceutically-acceptable acid-addition and base-addition salts thereof, characterised by cyclisation of a compound of the formula II: <CHEM> or a derivative thereof in which the carbonyl group is masked, or an acid-addition salt thereof, in which R<4> and R<5> individually have one of the values for R<2> and R<3>, R<6> is a nitrogen-protecting group and R<7> is hydrogen or any one of the cephalosporin 3-carboxylic acid protecting groups known in the art; whereafter when the product from the cyclisation reatains the protecting group R<7> (when R<7> is other than hydrogen) the protecting group R<7> is replaced by hydrogen by conventional means; and whereafter when the compound of the formula I is obtained in the form of the free base or salt, and a pharmaceutically-acceptable salt or free base respectively is required, any necessary conversion between free base and salt is carried out by conventional means.</p> |
申请公布号 |
HU191620(B) |
申请公布日期 |
1987.03.30 |
申请号 |
HU19830004255 |
申请日期 |
1983.12.14 |
申请人 |
ICI PHARMA,FR;IMPERIAL CHEMICAL INDUSTRIES PIC,GB |
发明人 |
JUNG,FREDERIC H.,FR;OLIVIER,ANNIE A.,FR;LOFTUS,FRANK,GB |
分类号 |
C07D501/16;C07D309/14;C07D501/18;C07D505/00;C07F7/10;(IPC1-7):C07D501/18 |
主分类号 |
C07D501/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|