PROCESS FOR PREPARING CEPHALOSPORIN DERIVATIVES

摘要

Cephalospolins (I) [R1=H or carboxyl-protecting gp. ; R2=a gp. (II)- (V); R6=H, OH, NO2, (thio)carbamoyl or opt. substd. alkyl, alkynyl, cycloalk(en)yl, NR16R17, etc.; R16=R17=H or alkyl; R7-R12 and R14- 15=H, halo, or opt. substd. alkyl, aralkyl, or aryl; R13=H, halo, carboxy, sulpho, etc.; R3=H or alkoxy; R4=H or halo; R5=H or opt. protected amino; A=methylene or :CN:N-OR18 (syn and/or anti); R18=H, alk(en)yl, alkynyl, cycloalk(en)yl, or a gp. -P(O)(R19)(R20), etc; R19=R20=OH, (ar)alkyl, aryl, (ar)alkoxy or aryloxy! and their salts are prepd. (I) are anti-bacterials with a broad spectrum of activity, good stability against betalactamase.